Best Fertility Centre in Hyderabad
Discover innovative fertility treatments at 9M Fertility, the
best IVF centre in Hyderabad, leading your path to parenthood.
Lymphocyte Immunization Therapy
(LIT)
Infertility is a common condition that affects many couples and individuals across the world. Assisted Reproductive Technologies (ART) such as IVF have become a beacon of hope for those struggling to conceive. However, what happens when IVF does not succeed or when pregnancies end in repeated miscarriages?
Advances in reproductive healthcare have highlighted the important role of immunological factors in fertility, especially in cases of recurrent pregnancy loss and unexplained infertility. Lymphocyte Immunization Therapy (LIT) is a specialised and advanced fertility treatment developed to address immune-related causes of implantation failure and miscarriage. It offers new hope to women and couples who have not achieved success through natural conception or repeated IVF cycles.
cycle)
What is Lymphocyte Immunization Therapy (LIT)?
Lymphocyte Immunization Therapy (LIT) is a minimally invasive, advanced fertility treatment that focuses on correcting immune system responses that may interfere with pregnancy. The procedure involves injecting lymphocytes, a type of white blood cell, collected from the male partner or, in certain cases, a donor, into the female partner. This exposure helps the maternal immune system recognise and tolerate the genetic material of the embryo, which contains contributions from both parents.
In some women with recurrent miscarriages, the immune system may mistakenly perceive the embryo as a foreign entity and trigger an immune response against it. LIT aims to modify this response by promoting immune tolerance, thereby supporting successful implantation and continuation of pregnancy.
How does LIT help improve fertility outcomes?
When immunological causes of unsuccessful embryo implantation are suspected, Lymphocyte Immunization Therapy (LIT) may be recommended. Since a developing embryo contains genetic material from both the mother and the father, the mother’s immune system may sometimes mistakenly recognise proteins from the paternal side as foreign and trigger an immune response against the embryo.
LIT is designed to prepare the maternal immune system for pregnancy by promoting immune tolerance rather than rejection. By introducing paternal lymphocytes, proteins, and antigens in a controlled and “friendly” manner before pregnancy, LIT helps the immune system adapt to these foreign cells. This reduces harmful immune reactions that could otherwise lead to implantation failure or early pregnancy loss, thereby supporting the continuation of pregnancy.
Who should consider LIT?
Lymphocyte Immunization Therapy (LIT) is primarily recommended for couples who face difficulty in carrying a pregnancy to term due to immune-related factors. Fertility specialists may advise this treatment for women who have experienced recurrent pregnancy loss, particularly those with three or more consecutive miscarriages, where immune dysfunction is suspected to be a contributing cause. LIT may also benefit couples who have undergone multiple unsuccessful IVF cycles, as repeated implantation failure can sometimes be linked to immune rejection of the embryo. In addition, for cases of unexplained infertility where immunological factors are believed to interfere with implantation or cause early pregnancy loss, LIT can help improve maternal fetal immune compatibility and enhance the chances of achieving a successful pregnancy.
Step 1: Collection of Lymphocytes
A small blood sample is drawn from the male partner or a screened donor. The blood is processed in a laboratory to isolate lymphocytes, which are essential for immune regulation.
Step 2: Processing of White Blood Cells
The collected lymphocytes are purified to remove unwanted components, ensuring that only the necessary immune cells are used for the therapy.
Step 3: Injection of Lymphocytes
The purified lymphocytes are injected just under the skin of the female partner, usually in the forearm, over a series of sessions. This controlled exposure helps the immune system recognize and accept the partner’s genetic material.
Step 4: Development of Immune Tolerance
The female immune system gradually develops tolerance toward the partner’s genetic material, reducing the risk of miscarriage and supporting successful implantation and pregnancy.
Benefits of LIT
• Can be combined with IVF and other fertility treatments
• Minimally invasive with a short recovery period
Safety and Side Effects
LIT is generally safe when performed under expert supervision. Mild side effects such as redness, swelling, or discomfort at the injection site may occur. Serious adverse reactions are rare. Patients are closely monitored throughout the treatment process to ensure safety and effectiveness.
Why Choose 9M Fertility for Lymphocyte Immunization Therapy (LIT)?
Experienced Specialists
9M Fertility is supported by skilled fertility specialists and reproductive immunology experts with experience in providing LIT using evidence-based protocols.
Personalised Treatment Plans
Each patient undergoes a detailed immunological assessment, allowing customised LIT protocols tailored to individual clinical needs.
Advanced Facilities
The centre is equipped with modern infrastructure and advanced laboratory support to ensure safety, accuracy, and high-quality care.
Comprehensive Support
Patients receive counselling before treatment and continued care after therapy, ensuring comfort, clarity, and confidence throughout the fertility journey.
Choosing 9M Fertility means placing your LIT care in the hands of a team that combines medical expertise, advanced technology, and compassionate support to help improve the chances of a healthy and successful pregnancy.
Frequently Asked Questions
Yes, LIT can improve pregnancy chances in couples with immune-related infertility or recurrent pregnancy loss, though results vary by individual.
The number of sessions depends on your immune response and clinical plan, usually determined by your fertility specialist.
Women with recurrent miscarriages, repeated IVF failures, or unexplained infertility linked to immune factors may benefit.
Yes, LIT is generally safe. Mild redness or swelling at the injection site may occur, but serious complications are rare.
Yes, LIT can be used alongside IVF or other fertility treatments to enhance implantation and pregnancy success.